期刊
PHYSICAL REVIEW LETTERS
卷 127, 期 9, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.127.198102
关键词
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资金
- Wellcome Trust [101050/Z/13/Z, 207510/Z/17/Z]
- Medical Research Council [MR/P000479/1]
- ERC [682754]
- Engineering and Physical Sciences Research Council [EP/M017982/1]
- Schlumberger Chair Fund
- EPSRC [EP/M017982/1] Funding Source: UKRI
- MRC [MR/P000479/1] Funding Source: UKRI
- Wellcome Trust [207510/Z/17/Z, 101050/Z/13/Z] Funding Source: Wellcome Trust
- European Research Council (ERC) [682754] Funding Source: European Research Council (ERC)
The cilia bundles in MCCs behave as active vortices, limiting their rate of work and shearing the tissue at a finite but low area coverage, which mirrors findings for other sparse distributions such as cell receptors and leaf stomata.
In tissues as diverse as amphibian skin and the human airway, the cilia that propel fluid are grouped in sparsely distributed multiciliated cells (MCCs). We investigate fluid transport in this mosaic architecture, with emphasis on the trade-offs that may have been responsible for its evolutionary selection. Live imaging of MCCs in embryos of the frog Xenopus laevis shows that cilia bundles behave as active vortices that produce a flow field accurately represented by a local force applied to the fluid. A coarse-grained model that self-consistently couples bundles to the ambient flow reveals that hydrodynamic interactions between MCCs limit their rate of work so that they best shear the tissue at a finite but low area coverage, a result that mirrors findings for other sparse distributions such as cell receptors and leaf stomata.
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