4.6 Article

Controlling the diversity of ion-induced fragmentation pathways by N-methylation of amino acids

期刊

PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 24, 期 2, 页码 941-954

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cp04097a

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资金

  1. Centre National de la Recherche Scientifique (CNRS)
  2. COST action - Molecular Dynamics in the GAS phase (MD-GAS) [CA18212]
  3. MICINN - Spanish Ministry of Science and Innovation - MCIN/AEI [PID2019-110091GB-I00, PID2019-105458RB-I00]
  4. 'Maria de Maeztu' Program for Centers of Excellence in RD [CEX2018-000805-M]
  5. 'Severo Ochoa' Programme for Centres of Excellence in RD [SEV-2016-0686]
  6. project INCa-ITMO within the Programme Plan Cancer (Inserm) [N PC201307]
  7. FPI [CTQ2016-76061-P]
  8. Region Normandie and Synchrotron SOLEIL

向作者/读者索取更多资源

This study focuses on the fragmentation of singly and doubly N-methylated glycine induced by low-energy O6+ ions. Coincidence measurements provide clear information on the origin of charged fragments, and the results show that single N-methylation leads to more fragmentation channels compared to no methylation, while double N-methylation effectively closes many of these channels. This closure of fragmentation channels does not imply a protective effect by the methyl group.
We present a combined experimental and theoretical study of the fragmentation of singly and doubly N-methylated glycine (sarcosine and N,N-dimethyl glycine, respectively) induced by low-energy (keV) O6+ ions. Multicoincidence mass spectrometry techniques and quantum chemistry simulations (ab initio molecular dynamics and density functional theory) allow us to characterise different fragmentation pathways as well as the associated mechanisms. We focus on the fragmentation of doubly ionised species, for which coincidence measurements provide unambiguous information on the origin of the various charged fragments. We have found that single N-methylation leads to a larger variety of fragmentation channels than in no methylation of glycine, while double N-methylation effectively closes many of these fragmentation channels, including some of those appearing in pristine glycine. Importantly, the closure of fragmentation channels in the latter case does not imply a protective effect by the methyl group.

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