期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 36, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2021.102520
关键词
Optical coherence tomography; Photodynamic therapy; Skin cancer
类别
This study demonstrated the technical feasibility of using OCT to map tumor margins and monitor skin changes post-PDT, as well as optimize treatment efficacy. OCT images showed distinct microstructural differences between different skin tissues, providing valuable information for histological analysis of skin lesions.
Background: The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. Material and Methods: A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to determine tumor free margins. Monitoring of the healing process was undertaken at 3, 6 and 12 months post-PDT. Parameters measured by the in vivo OCT during healing phase were the organization of skin layer and the degree skin fibroses for the active center and peripheral transit zone of the treated lesion. Clinical and aesthetics assessment was carried out at 12-month post-PDT. Results: Distinct microstructural differences between normal skin, pre-cancer, cancer, and the transition zone between the two tissues were observed on OCT images. In the subsequent healing phase, OCT demonstrate marked delineation and organization of skin layer at late stage of healing. Early features showing bizarre nonhomogenous disorganized layering (scab) but afterwards, OCT was able to differentiate between different histological layers. One lesion demonstrated clinical healing by fibrosis (scar) without sign of recurrence. Another lesion demonstrated skin erythema. Only one lesion did not response to treatment despite margins clearance. The CR rate was 95% at the end of the study. The cosmetic effect was excellent in 89% of the patients. Conclusions: This feasibility study lays the groundwork for using OCT as a real-time, noninvasive monitoring device for PDT in patients with skin cancer.
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