期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 36, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2021.102484
关键词
Photodynamic therapy; Wound Healing; Infection; Treatment
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology in Japan ([JSPS] KAKENHI Grant) [17K11584]
- Japan Agency for Medical Research and Development (AMED) [JP20fk0108133]
- Grants-in-Aid for Scientific Research [17K11584] Funding Source: KAKEN
The study showed that ALA-PDT is a safe and effective treatment for skin ulcers infected with MRSA and PA, achieving infection control and promoting wound healing.
Background: Drug-resistant bacterial infections are a global problem. Novel treatment methods that simultaneously control infection and promote wound healing without leading to new resistant bacteria are needed. Photodynamic therapy (PDT) is a useful antibiotic-free treatment approach. Our previous studies have shown that PDT for skin ulcers infected with methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA) can achieve infection control and promoting wound healing in vitro and in vivo murine model. Here, we investigated the safety and effectiveness of PDT with 5-aminolevulinic acid (ALA-PDT) for human skin ulcers infected with MRSA and PA. Methods: ALA-PDT with macrogol ointment containing 0.5% ALA-HCl and 0.005% EDTA-2Na (wavelength 410 nm, 10 J/cm(2)) was performed on consecutive days in patients aged >= 20 years who had skin ulcers infected with MRSA and PA. Results: Six of our seven patients showed a clear tendency for ulcer area reduction to <= 60% of that measured at baseline. ALA-PDT was judged to be completely safe in all patients; only one patient had an increase in bacterial count. Conclusions: ALA-PDT is safe and effective for MRSA and PA infected skin ulcers to control and heal wound.
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