期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 38, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2022.102770
关键词
Silver(II) porphyrins; Mycobacteria; Antimicrobial activity; Photodynamic therapy
类别
资金
- CNPq
- CAPES
- FAPERGS
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq - Brazil) [409150/2018-5, 304711/2018-7, 404541/2016-0]
- MCTIC/CNPq [465452/2014-0]
- FAPESP [2014/50906-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
- INCT/INOMAT (National Institute for Complex Functional Materials) [MCT/Finep/CT-Infra 02/2010]
- Atlas Assessoria Linguistica
In this study, the photoinactivation evaluation of Ag(II) porphyrins in the antimicrobial photodynamic therapy of rapidly growing mycobacterial strains was reported. The results showed that Ag(II) porphyrins significantly reduced the concentration of viable mycobacteria and induced potential structural damage.
We report the photoinactivation evaluation of Ag(II) porphyrins (cationic AgTMeP and anionic AgTPPS) in the antimicrobial photodynamic therapy (aPDT) of rapidly growing mycobacterial strains. The aPDT assays in the Mycolicibacterium fortuitum, Mycobacteroides abscessus subs. abscessus, Mycobacteroides abscessus subsp. massiliense, and Mycolicibacterium smegmatis strains conducted without aggregating photosensitizers (PS) under irradiation for 90 min (270 J/cm(2)) showed that the most effective PS (nanomolar range) significantly reduced the concentration of viable mycobacteria. Structural damage on the Mycolicibacterium smegmatis non-pathogenic model was observed using atomic force microscopy, revealing that Ag(II)-porphyrin induced extensive changes in its electrical and adhesive forces, demonstrating changes in topography that may be linked to the action of different fractions of reactive oxygen species. The results presented in this paper provide solid evidence for using cationic porphyrin AgTMeP as an alternative to the conventional treatment of cutaneous mycobacteriosis and the disinfection of prosthetic devices and hospital equipment.
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