The synthons containing sulfur and stereogenic phosphorus as heteroatoms: on the way to crystal structure determination of supramolecular complexes of organometallic and organic compounds

The purpose of this study is to contribute to the process of establishing correlation between the three-dimensional structure of the chemical complex and enantiomeric yield of a stereospecific reaction. To achieve this goal, we synthesized, and will complexate with metal cations and organometallic moieties, the compounds which contain stereogenic heteroatom namely the optically active P-stereogenic phosphinic acid derivatives containing heavy atom such as sulfur. Our chiral thioacids, which we obtained in enantiomeric forms, are proposed to serve as new catalysts to replace the achiral copper acetate and palladium acetate, used routinely as catalysts in the reactions which require additional presence of another chiral ligand to assure the enantiomeric yield. Hereby we would like to present the progress on the X-ray structure determination of our synthesized series of thiophosphinic acids 1.

Automated summary

The purpose of this study is to investigate the correlation between the three-dimensional structure of a chemical complex and the enantiomeric yield of a stereospecific reaction. By synthesizing optically active P-stereogenic phosphinic acid derivatives, complexating them with metal cations and organometallic moieties, and replacing achiral catalysts with chiral thioacids obtained in enantiomeric forms, this study aims to develop new catalysts for reactions that require the presence of a chiral ligand. The progress made in the X-ray structure determination of a series of synthesized thiophosphinic acids is presented.