4.5 Article

Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys

期刊

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2021.173300

关键词

Marmoset; Object recognition; Memory; Scopolamine; MK-801; Donepezil

资金

  1. CAPES
  2. CNPq [305525/2018-2, 310719/2017-8]

向作者/读者索取更多资源

The study found that the competitive muscarinic acetylcholine receptor antagonist scopolamine and the noncompetitive N-methylD-aspartate glutamate receptor antagonist MK-801 can both affect the performance of marmosets in the spontaneous object recognition task. The acetylcholinesterase inhibitor donepezil can reverse the memory deficit caused by the former.
The spontaneous object recognition (SOR) task is one of the most widely used behavioral protocols to assess visual memory in animals. However, only recently was it shown that nonhuman primates also perform well on this task. Here we further characterized this new monkey recognition memory test by assessing the performance of adult marmosets after an acute systemic administration of two putative amnesic agents: the competitive muscarinic acetylcholine receptor antagonist scopolamine (SCP; 0.05 mg/kg) and the noncompetitive N-methylD-aspartate glutamate receptor antagonist MK-801 (0.015 mg/kg). We also determined whether the acetylcholinesterase inhibitor donepezil (DNP; 0.50 mg/kg), a clinically-used cognitive enhancer, reverses memory deficits caused by either drug. The subjects had an initial 10 min sample trial where two identical neutral objects could be explored. After a 6 h retention interval, recognition was based on an exploratory preference for a new rather than familiar object during a 10 min test trial. Both SCP and MK-801 impaired the marmosets' performance on the SOR task, as both objects were explored equivalently. Co-administration of 0.50 mg/kg of DNP reversed the SCP- but not the MK-801-induced memory deficit. These results indicate that cholinergic and glutamatergic pathways mediate object recognition memory in the monkey SOR task.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据