期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 210, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2021.173273
关键词
Object recognition; Morris water maze; Hippocampal impairment; Cognitive deficit; Debate; Difficulties
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Universidade Federal do Rio Grande do Sul
- Instituto Nacional de Ciencia eTecnologia para Excitotoxicidade e Neuroprotec ao (INCTEN/CNPq)
Object recognition (OR) and the Morris water maze (MWM) are classical tasks used to assess memory parameters in rodents, involving hippocampus and prefrontal cortex connections. Despite controversy, these tests offer practical tools for evaluating hippocampal-related memory deficits in rats, with minimal manageable stressful conditions.
Object recognition (OR) and the Morris water maze (MWM) are classical tasks widely used to assess memory parameters and deficits in rodents. Learning processes in both tasks involve integrity of the hippocampus and associated regions, and prefrontal cortex connections. Here, we highlight the idea that these classical tests can be used to indicate memory deficits caused by models of disease that affect hippocampal function in rats, and identify some practical issues of OR and MWM, based on the literature and our experience. Additionally, we have shown that the performance of both tasks does not alter blood levels of corticosterone, considering exposure to a single task. Hence, taking into consideration the difficulties and care required during task execution, the infrastructure needed and the training of the experimenter, we suggest that OR and its variations offer minimal manageable stressful conditions, representing an effective and practical tool for hippocampal-related memory assessment of rats. Thus, OR may provide similar information to that of the MWM, despite controversy regarding hippocampus participation in OR and given due differences in the types of memory evaluated and researchers' objectives. We recommend the observation of some important precautions and details, also based on the literature and our own experience.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据