期刊
PHARMACOLOGICAL RESEARCH
卷 172, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105849
关键词
Nonalcoholic steatohepatitis; Traditional Chinese medicine; Lipid metabolism; Inflammation; Fibrosis; Gut microbiota; Review
资金
- National Natural Science Foundation of China [82104746, 81974558]
- Sanming Project of Medicine in Shenzhen, Guangdong Province, China [SZSM201612074, SZSM201612033]
- Shenzhen Municipal Scheme for Basic Research [JCYJ20190808144005614]
NASH is a common chronic liver disease in clinical practice with no officially approved pharmacological therapy. Traditional Chinese medicine has been proven beneficial in treating NASH in multiple studies, providing a potential therapy for this condition.
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease in clinical practice. It has been considered that NASH is one of the main causes of chronic liver disease, cirrhosis and carcinoma. The mechanism of the NASH progression is complex, including lipid metabolism dysfunction, insulin resistance, oxidative stress, inflammation, apoptosis, fibrosis and gut microbiota dysbiosis. Except for lifestyle modification and bariatric surgery, there has been no pharmacological therapy that is being officially approved in NASH treatment. Traditional Chinese medicine (TCM), as a conventional and effective therapeutic strategy, has been proved to be beneficial in treating NASH in numbers of studies. In the light of this, TCM may provide a potential therapy for treating NASH. In this review, we summarized the associated mechanisms of action TCM treating NASH in preclinical studies and systematically analysis the effectiveness of TCM treating NASH in current clinical trials.
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