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Muhammad Imran et al.
FOOD SCIENCE & NUTRITION (2021)
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Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells
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Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
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GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae through β-Catenin Activation
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways
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Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
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Fisetin inhibits vascular endothelial growth factor-induced angiogenesis in retinoblastoma cells
Liangjun Wang et al.
ONCOLOGY LETTERS (2020)
Flavonoids Restore Platinum Drug Sensitivity to Ovarian Carcinoma Cells in a Phospho-ERK1/2-Dependent Fashion
Yifat Koren Carmi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation
Guoping Ding et al.
CELL DEATH & DISEASE (2020)
Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
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PLOS ONE (2020)
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification
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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Preparation and optimization of poly (lactic acid) nanoparticles loaded with fisetin to improve anti-cancer therapy
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)
Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
Shengnan Jia et al.
CELL DEATH & DISEASE (2019)
Fisetin activates Hippo pathway and JNK/ERK/AP-1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression
Chien-Yao Fu et al.
ENVIRONMENTAL TOXICOLOGY (2019)
Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer
Naghma Khan et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2α Activation to Enhance Fisetin-induced Chemosensitivity in HDAC Inhibitor-resistant Hepatocellular Carcinoma Cells
Yi-Sheng Liu et al.
CANCERS (2019)
Targeting Autophagy in Cancer: Recent Advances and Future Directions
Ravi K. Amaravadi et al.
CANCER DISCOVERY (2019)
Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway
Gang Guo et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)
Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell
Yibing Si et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)
Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma
Bong-Soo Park et al.
JOURNAL OF CANCER (2019)
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer
Charly Ryan Good et al.
CANCER RESEARCH (2018)
Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
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LIFE SCIENCES (2018)
DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells
Kyoung Ah Kang et al.
REDOX BIOLOGY (2018)
Evidence for the Involvement of the Master Transcription Factor NF-B in Cancer Initiation and Progression
Yu Rou Puar et al.
BIOMEDICINES (2018)
Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction
Bin Shi et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
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MOLECULES (2017)
Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor
Xiang-Feng Liu et al.
ONCOLOGY REPORTS (2017)
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TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis
Min Deng et al.
CANCER RESEARCH (2017)
TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer
Xi Han et al.
CELL BIOLOGY INTERNATIONAL (2017)
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles
Amrita Kadari et al.
DRUG DELIVERY (2017)
Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway
Ming-Te Lin et al.
TUMOR BIOLOGY (2016)
Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
Harish C. Pal et al.
ONCOTARGET (2016)
Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signaling pathways
Xi-Jun Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2016)
Identification of MLL-fusion/MYC miR-26 TET1 signaling circuit in MLL-rearranged leukemia
Hao Huang et al.
CANCER LETTERS (2016)
Preparation of albumin based nanoparticles for delivery of fisetin and evaluation of its cytotoxic activity
Pooja Ghosh et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)
Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells
Eiman Mukhtar et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Dietary flavonoid fisetin for cancer prevention and treatment
Rahul K. Lall et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2016)
Counting on natural products for drug design
Tiago Rodrigues et al.
NATURE CHEMISTRY (2016)
Integrating network reconstruction with mechanistic modeling to predict cancer therapies
Melinda Halasz et al.
Science Signaling (2016)
Integrating network reconstruction with mechanistic modeling to predict cancer therapies
Melinda Halasz et al.
Science Signaling (2016)
MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA
Weiying Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor
Ana Sebio et al.
CLINICAL CANCER RESEARCH (2015)
The re-emergence of natural products for drug discovery in the genomics era
Alan L. Harvey et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Personalized genomic analyses for cancer mutation discovery and interpretation
Sian Jones et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells
Harish Chandra Pal et al.
ONCOTARGET (2015)
Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling
Deeba N. Syed et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Tumor Activity and Safety Evaluation of Fisetin-Loaded Methoxy Poly(ethylene glycol)-Poly(ε-Caprolactone) Nanoparticles
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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014)
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
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NATURE REVIEWS DRUG DISCOVERY (2014)
Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways
Harish Chandra Pal et al.
PLOS ONE (2014)
YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin
Mohammad Imran Khan et al.
ONCOTARGET (2014)
Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway
Ruey-Hwang Chou et al.
PLOS ONE (2013)
TET1 plays an essential oncogenic role in MLL-rearranged leukemia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Hippo pathway and human cancer
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NATURE REVIEWS CANCER (2013)
Fisetin inhibits various attributes of angiogenesis in vitro and in vivo-implications for angioprevention
Tariq A. Bhat et al.
CARCINOGENESIS (2012)
Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
Naghma Khan et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice
Heloise Ragelle et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)
Fisetin, a Dietary Flavonoid, Induces Cell Cycle Arrest and Apoptosis through Activation of p53 and Inhibition of NF-Kappa B Pathways in Bladder Cancer Cells
Jing Li et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2011)
Inhibition of Human Melanoma Cell Growth by the Dietary Flavonoid Fisetin Is Associated with Disruption of Wnt/β-Catenin Signaling and Decreased Mitf Levels
Deeba N. Syed et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Autophagy as a target for anticancer therapy
Filip Janku et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
Yewseok Suh et al.
CARCINOGENESIS (2010)
Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells
Chi-Sheng Chien et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
C. A. Sparks et al.
ONCOGENE (2010)
Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin
Do Y. Lim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-κB-signaling pathways
Yewseok Suh et al.
CARCINOGENESIS (2009)
Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-inediated inhibition of NF-κB
Imtiyaz Murtaza et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
Jesse W. -H. Li et al.
SCIENCE (2009)
IAP-targeted therapies for cancer
E. C. LaCasse et al.
ONCOGENE (2008)
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IκBα kinase activation
Bokyung Sung et al.
MOLECULAR PHARMACOLOGY (2007)
Current development of mTOR inhibitors as anticancer agents
Sandrine Faivre et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
The evolving role of natural products in drug discovery
FE Koehn et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
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NATURE GENETICS (2004)