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Hardeep Singh Tuli et al.
PHARMACOLOGICAL RESEARCH (2021)
Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells
Weibo Liao et al.
ANTIVIRAL RESEARCH (2020)
Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization
Feng Gao et al.
CELL DEATH & DISEASE (2020)
Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90)
Cong-Truong Nguyen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent
Haipin Zhou et al.
FITOTERAPIA (2020)
An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target
Sung-Jun Hong et al.
BIOMEDICINES (2020)
Molecular interaction studies of Deguelin and its derivatives with Cyclin D1 and Cyclin E in cancer cell signaling pathway: The computational approach
Kiran Bharat Lokhande et al.
SCIENTIFIC REPORTS (2019)
Investigation of B, C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents
Ho Shin Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential
Rake Sarah Varughese et al.
CANCER (2019)
Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors
Hong Yao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAFV600E mutation bearing metastatic melanoma cells
Evan L. Carpenter et al.
MOLECULAR CARCINOGENESIS (2019)
Inhibition of Cancer Stem-Like Phenotype by Curcumin and Deguelin in CAL-62 Anaplastic Thyroid Cancer Cells
Mehmet A. Kocdor et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2019)
Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Liubo Chen et al.
CANCER MANAGEMENT AND RESEARCH (2019)
Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox)
Aimei Wang et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)
Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
Ming Li et al.
ONCOTARGET (2018)
Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway
Wei Li et al.
CELLULAR SIGNALLING (2018)
Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells
Wei Li et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)
Novel Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy
Hongchan An et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer
Seung Yeob Hyun et al.
SCIENTIFIC REPORTS (2018)
Antitumor Effects of Deguelin on H460 Human Lung Cancer Cells In Vitro and In Vivo: Roles of Apoptotic Cell Death and H460 Tumor Xenografts Model
Yu-Chieh Hsu et al.
ENVIRONMENTAL TOXICOLOGY (2017)
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma
Yuh Baba et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin
Xiao Dong Xu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
Wei Li et al.
ONCOTARGET (2017)
Deguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2
Dejian Zhao et al.
THORACIC CANCER (2017)
Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma
Xinfang Yu et al.
EBIOMEDICINE (2017)
Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro
Xia Zhang et al.
ANTI-CANCER DRUGS (2017)
Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity
Su-Chan Lee et al.
CANCER RESEARCH (2016)
Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling
Yu-Peng Liu et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2016)
Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer
Andrew J. Robles et al.
BREAST CANCER RESEARCH AND TREATMENT (2016)
Deguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1
Bing Yan et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)
Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
Wen Zheng et al.
ONCOLOGY LETTERS (2016)
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model
Nerea Rebolleda et al.
PLOS ONE (2016)
Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity
Wei Wu et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2016)
Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway
Huae Xu et al.
CANCER CELL INTERNATIONAL (2015)
Hsp90 Activity Modulation by Plant Secondary Metabolites
Fabrizio Dal Piaz et al.
PLANTA MEDICA (2015)
Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion
Minh Phuong Nguyen et al.
ONCOTARGET (2015)
Deguelin Induces Apoptosis by Targeting Both EGFR-Akt and IGF1R-Akt Pathways in Head and Neck Squamous Cell Cancer Cell Lines
Yuh Baba et al.
BIOMED RESEARCH INTERNATIONAL (2015)
Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation
Sha Yi et al.
ANNALS OF HEMATOLOGY (2015)
Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine
Saurabh Bundela et al.
PLOS ONE (2015)
Inhibition of Survivin Restores the Sensitivity of Breast Cancer Cells to Docetaxel and Vinblastine
Parisa Ghanbari et al.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2014)
Nontoxic-dose of Deguelin Induce NPMc plus AML Cell Differentiation by Selectively Targeting Mt NPM1/SIRT1 Instead of HDAC1/3
You Ping Wang et al.
CURRENT CANCER DRUG TARGETS (2014)
Natural product inhibitors of ocular angiogenesis
Rania S. Sulaiman et al.
EXPERIMENTAL EYE RESEARCH (2014)
Deguelin Inhibits the Migration and Invasion of U-2 OS Human Osteosarcoma Cells via the Inhibition of Matrix Metalloproteinase-2/-9 in Vitro
Hung-Sheng Shang et al.
MOLECULES (2014)
Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells
Zhengguang Li et al.
ONCOLOGY LETTERS (2014)
A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer
Young-Ah Suh et al.
CANCER LETTERS (2013)
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
Rajeshwari R. Mehta et al.
CLINICAL & EXPERIMENTAL METASTASIS (2013)
Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model
S. R. Boreddy et al.
ONCOGENE (2013)
Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells
Yan-li Yang et al.
PLOS ONE (2013)
Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
Rajeshwari Mehta et al.
PLOS ONE (2013)
NATURALLY OCCURRING SUBSTANCES AND THEIR ROLE IN CHEMO-PROTECTIVE EFFECTS
Miroslava Bilecova-Rabajdova et al.
CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH (2013)
Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
Ying Wang et al.
MOLECULAR AND CLINICAL ONCOLOGY (2013)
Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature
Bharat Aggarwal et al.
CURRENT COLORECTAL CANCER REPORTS (2013)
Deguelin, an Akt Inhibitor, Down-Regulates NF-κB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice
Hyoun Woo Kang et al.
DIGESTIVE DISEASES AND SCIENCES (2012)
Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis
Dong-Jo Chang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system
Ke Men et al.
NANOSCALE (2012)
The autophagic paradox in cancer therapy
W. K. K. Wu et al.
ONCOGENE (2012)
Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis
Zhengguang Li et al.
ONCOLOGY LETTERS (2012)
Deguelin-an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model
Jia Hu et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway
Genoveva Murillo et al.
CANCER PREVENTION RESEARCH (2009)
Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α
Woo-Young Kim et al.
CANCER RESEARCH (2009)
A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
Woo-Young Kim et al.
CANCER PREVENTION RESEARCH (2008)
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha
Seung-Hyun Oh et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin
Quanri Jin et al.
CANCER RESEARCH (2007)
Structural basis for depletion of heat shock protein 90 client proteins by deguelin
Seung Hyun Oh et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-κB pathway
Raffaella Dell'Eva et al.
CARCINOGENESIS (2007)
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells
HY Lee et al.
CLINICAL CANCER RESEARCH (2004)
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells
HY Lee
BIOCHEMICAL PHARMACOLOGY (2004)
Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease
P Caboni et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
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