期刊
PHARMACOLOGICAL RESEARCH
卷 172, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105760
关键词
Ion channel; Taste sensation; Taste receptor cells; Signaling transduction; Epigenetics
资金
- National Natural Science Foundation of China [81872218]
- West China School/Hospital of Stomatology Sichuan University [RCDWJS20208]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2019I2M-5-004]
Taste is mediated by specialized neuroepithelial cells called taste receptor cells located at tongue papillae. Ion channels play a crucial role in various cell physiological activities, while epigenetic modifications regulate gene expression without altering DNA sequence.
There are five fundamental tastes discovered so far: sweet, bitter, umami, sour and salty. Taste is mediated by the specialized neuroepithelial cells mainly located at the tongue papillae, namely taste receptor cells, which can be classified into type I, type II, type III and type IV. Ion channels are necessary for diverse cell physiological activities including taste sensing, smell experience and temperature perception. Existing evidences have demonstrated distinct structures and working models of ion channels. Epigenetic modifications regulate gene expression mainly through histone modifications, DNA methylation and non-coding RNA-mediated regulation, without altering DNA sequence. This review summarizes how ion channels work during the transduction of multiple tastes, as well as the recent progressions in the epigenetic regulation of ion channels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据