期刊
PHARMACOLOGICAL RESEARCH
卷 172, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105833
关键词
Autoimmune disease; Nanoparticle; Extracellular vesicle; Mesenchymal stromal cell; Immunomodulation; Immunosuppression
资金
- China Scholarship Council [202006370067]
Nanotechnology offers potential to improve the treatment of autoimmune diseases by reducing side effects and enhancing immunosuppressive capacity. This review discusses the properties and mechanisms of synthesized nanoparticles, biomimetic nanoparticles, and extracellular vesicles, and their immunomodulation properties. The challenges faced by these nanoparticles are also described.
An emerging strategy is needed to treat autoimmune diseases, many of which are chronic with no definitive cure. Current treatments only alleviate symptoms and have many side effects affecting patient quality of life. Recently, nanoparticle drug delivery systems, an emerging method in medicine, has been used to target cells or organs, without damaging normal tissue. This approach has led to fewer side effects, along with a strong immunosuppressive capacity. Therefore, a nanotechnology approach may help to improve the treatment of autoimmune diseases. In this review, we separated nanoparticles into three categories: synthesized nanoparticles, biomimetic nanoparticles, and extracellular vesicles. This review firstly compares the typical mechanism of action of these three nanoparticle categories respectively in terms of active targeting, camouflage effect, and similarity to parent cells. Then their immunomodulation properties are discussed. Finally, the challenges faced by all these nanoparticles are described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据