Antiproliferative Activity of 3-Cyanocoumarins and 2-Aminochromeno[2,3-b ]Pyridine-3-Carbonitriles, Derivatives of 2-Amino-4H-Chromene-3-Carbonitrile

The antiproliferative activity of the previously synthesized 2-amino-4H-chromene-3-carbonitrile derivatives 4,7-disubstituted 3-cyanocoumarins and 2-aminochromeno[2,3-b]pyridine-3-carbonitriles was studied on 59 cell lines isolated from lung, colon, brain, ovary, kidney, prostate, and breast tumors and leukemia and human melanoma. The reference drugs were dacarbazine, hydroxycarbamide, and cisplatin. It was found that the activity of the test substances was directly related to the nature of the 4- and 7-substituents. 4-Aryl-2-oxo-2H-benzo [h]chromene-3-carbonitriles showed the most pronounced activity and could be of interest as parent substances for potential anticancer drugs.

Automated summary

The antiproliferative activity of 2-amino-4H-chromene-3-carbonitrile derivatives on various tumor cell lines was studied, with 4-aryl-2-oxo-2H-benzo[h]chromene-3-carbonitriles showing the most promising activity. These findings provide valuable information for the development of potential anticancer drugs.