4.6 Article

Anti-inflammatory action of geniposide promotes wound healing in diabetic rats

期刊

PHARMACEUTICAL BIOLOGY
卷 60, 期 1, 页码 294-299

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2022.2030760

关键词

Diabetic skin lesion; interleukin-10; fasting plasma glucose; glycated haemoglobin

资金

  1. Science and Technology Project of Jiangxi Provincial Department of Education [GJJ180971, GJJ202016]
  2. National Natural Science Foundation of China [819601113]
  3. Science and Technology Plan Project of Jiangxi Provincial Health Commission [20204112, 20193013]
  4. School-Level Natural Science Project of Jiangxi University of Science and Technology [ZR2001]

向作者/读者索取更多资源

This study shows that geniposide promotes wound healing in diabetic rats through its anti-inflammatory action, reducing inflammatory cell infiltration and fibroblast proliferation. It also modulates the expression levels of pro-inflammatory factors. Further research is needed to evaluate its antibacterial activity and effects on skin regeneration.
Context As a major active iridoid glycoside from Gardenia jasminoides J. Ellis (Rubiaceae), geniposide possesses various pharmacological activities, including anti-platelet aggregation and anti-inflammatory action. Objectives This study explores the effect of geniposide in diabetic wound model by anti-inflammatory action. Materials and methods Diabetic rodent model in Wistar rats was induced by streptozotocin combined with high-fat feed. The selected rats were divided into control group, the diabetic model group and geniposide subgroups (200, 400 and 500 mg/kg), and orally administrated once daily with saline or geniposide. Wound area and histochemical indicators were measured on day 7 after continuous administration, to assess lesion retraction, inflammatory cells and fibroblasts. Results Geniposide notably enhanced lesion retraction by 1.06-1.84 times on day 7 after surgical onset in diabetic rats (p < 0.05). In the pathological experiment by HE staining, geniposide significantly reduced inflammatory cell infiltration and proliferation of fibroblasts in the central lesion regions. In diabetic rats treated with geniposide, the levels of pro-inflammatory factors (tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta)) and IL-6 were significantly reduced (p < 0.05), followed with the increment of IL-10 in a dose-dependent manner. The IC50 of geniposide on TNF-alpha, IL-1 beta and IL-6 could be calculated as 1.36, 1.02 and 1.23 g/kg, respectively. It assumed that geniposide-induced IL-10 expression contributed to inhibiting the expression of pro-inflammatory factors. Discussion and conclusions Geniposide promoted diabetic wound healing by anti-inflammation and adjusting blood glucose. Further topical studies are required to evaluate effects on antibacterial activity and skin regeneration.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据