4.6 Article

Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes

期刊

PHARMACEUTICAL BIOLOGY
卷 60, 期 1, 页码 225-234

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2021.2025255

关键词

Cordycepin; adenosine; anti-ageing; anti-skin wrinkle

资金

  1. Research and Researchers for Industries (RRi) [MSD62I0068]
  2. Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Thailand
  3. Research Center of Pharmaceutical Nanotechnology, Research Center of Pharmaceutical Nanotechnology, Chiang Mai University, Thailand
  4. Graduate School at Chiang Mai University
  5. CMU Presidential Scholarship 2020
  6. CMU Presidential Scholarship 2021

向作者/读者索取更多资源

This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes. The extracts from both fungi were found to contain a wide range of bioactive compounds, with the fruiting body extract of I. tenuipes showing exceptional antioxidant and anti-wrinkle properties.
Context Cordyceps militaris and Isaria tenuipes (Cordycipitaceae) are high-value fungi that are used for health-promoting food supplements. Since laboratory cultivation has begun for these fungi, increased output has been achieved. Objective This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes. Materials and methods The antioxidative potential of 10% v/v aqueous infused extract from each fungus was separately investigated using 2,2-azinobis(3-ethylbenzo-thiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant ability, and ferric thiocyanate methods. The inhibition against MMP-1, elastase, and hyaluronidase were determined to reveal their anti-wrinkle potential. Anti-tyrosinase activities were determined. Results C. militaris and I. tenuipes extracts were found to contain a wide range of bioactive compounds, including phenolics, flavonoids, and adenosine. A correlation was discovered between the chemical compositions and their biological activities. The extract from I. tenuipes fruiting body (IF) was highlighted as an extraordinary elastase inhibitor (IC50 = 0.006 +/- 0.004 mg/mL), hyaluronidase inhibitor (IC50: 30.3 +/- 3.2 mg/mL), and antioxidant via radical scavenging (ABTS IC50: 0.22 +/- 0.02 mg/mL; DPPH IC50: 0.05 +/- 0.02 mg/mL), thereby reducing ability (EC1: 95.3 +/- 4.8 mM FeSO4/g extract) and lipid peroxidation prevention (IC50: 0.40 +/- 0.11 mg/mL). IF had a three-times higher EC1 value than ascorbic acid and significantly higher elastase inhibition than epigallocatechin gallate. Discussion and conclusions IF is proposed as a powerful natural extract with antioxidant and anti-wrinkle properties; therefore, it is suggested for further use in pharmaceutical, cosmeceutical, and nutraceutical industries.

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