期刊
PEPTIDES
卷 146, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2021.170644
关键词
Host Defense Peptides; Immunomodulation; Innate immunity
资金
- German Federal Ministry of Education and Research (BMBF) [DLR CUB 17WTZ-014/01DN18009]
- German Research Society (DFG), Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents, Ulm University, Germany [CRC1279]
- DAAD-Germany of the German Ministry for Foreign Affairs via the program Global Health and Pandemic Prevention Centers [57592717-Glacier]
Host defense peptides (HDPs) have both antimicrobial and immunomodulatory activities, with the latter gaining increased interest in the past 20 years. The immunomodulatory activities are more effective in vivo, offering new therapeutic applications in areas such as anti-infective therapy, chronic inflammatory diseases treatment, novel vaccine adjuvants development, and anticancer immunotherapy.
Host defense peptides (HDPs) exhibit a broad range of antimicrobial and immunomodulatory activities. In this sense, both functions are like different sides of the same coin. The direct antimicrobial side was discovered first, and widely studied for the development of anti-infective therapies. In contrast, the immunomodulatory side was recognized later and in the last 20 years the interest in this field has been continuously growing. Different to their antimicrobial activities, the immunomodulatory activities of host defense peptides are more effective in vivo. They offer a great opportunity for new therapeutic applications in the fields of anti-infective therapy, chronic inflammatory diseases treatment, novel vaccine adjuvants development and anticancer immunotherapy. These immune related functions of HDPs includes chemoattraction of leukocytes, modulation of inflammation, enhancement of antigen presentation and polarization of adaptive immune responses. Our attempt with this review is to make a careful evaluation of different aspects of the less explored, but attractive immunomodulatory side of the HDP functional coin.
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