期刊
PEPTIDES
卷 148, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2021.170681
关键词
Ghrelin; GHS-R; Pancreatic islet; Insulin secretion; Blood glucose; Paracrine; alpha-cell; beta-cell; delta-cell; epsilon-cell
资金
- Japan Society for the Promotion of Science (JSPS) [19H04045, 26670453, 19K22611]
- Programs for the Strategic Research Foundation at Private Universities 2013-2017 - Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Advanced Research and Development Programs for Medical Innovation (AMED-CREST) 2015-2020 from Japan Agency for Medical Research and development (AMED)
- Grants-in-Aid for Scientific Research [19K22611, 19H04045] Funding Source: KAKEN
Ghrelin is expressed in both pancreatic islet cells and the stomach, and it physiologically restricts insulin release in rodents. Research focuses on the release of ghrelin from islet cells, the target cells of ghrelin in the islets, and the mechanisms by which islet-derived ghrelin inhibits insulin secretion.
Ghrelin is expressed in the pancreatic islet cells as well as the stomach. In the perfused pancreas and isolated islets, GHS-R antagonism, ghrelin immunoneutralization and ghrelin-knockout (Ghr-KO) all increase glucose-induced insulin release. Thus, pharmacological, immunological and genetic blockades of ghrelin in the pancreatic islets all markedly augment glucose-induced insulin release, showing that islet-derived ghrelin physiologically restricts insulin release in rodents. In this review, we focus on the current understanding of the following key questions: 1) from which islet cells ghrelin is released, 2) on which islet cells ghrelin acts, and 3) mechanisms by which the islet-derived ghrelin inhibits insulin secretion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据