Off-Label Prescription of COVID-19 Vaccines in Children: Clinical, Ethical, and Legal Issues

Review Pediatrics

COVID-19 in childhood: Transmission, clinical presentation, complications and risk factors

Melissa K. Siebach et al.

Summary: Children account for a small percentage of global COVID-19 cases, with most cases being mild or asymptomatic, but there are rare instances of complications. Older children have a higher infection rate, while there may be a risk of vertical transmission in neonates.

PEDIATRIC PULMONOLOGY (2021)

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Article Medicine, General & Internal

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

Robert W. Frenck et al.

Summary: The BNT162b2 vaccine showed favorable safety profile and a greater immune response in 12-to-15-year-old recipients compared to young adults, and demonstrated high effectiveness against Covid-19.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Pediatrics

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Mayme Marshall et al.

Summary: This report presents 7 cases of acute myocarditis or myopericarditis in healthy male adolescents following the second dose of Pfizer-BioNTech COVID-19 vaccination, with patients rapidly recovering their symptoms through treatment with nonsteroidal anti-inflammatory drugs, intravenous immunoglobulin, and corticosteroids. The potential association between vaccine administration and myocarditis requires further monitoring and investigation.

PEDIATRICS (2021)

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Article Medicine, General & Internal

Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform

Elizabeth J. Williamson et al.

Summary: The study found that individuals with learning disabilities in England have significantly increased risks of hospital admission and death from covid-19, highlighting the need for prompt access to covid-19 testing and healthcare for this vulnerable group. Prioritisation for covid-19 vaccination and other targeted preventive measures should be considered.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

Lyudmyla Kompaniyets et al.

Summary: This study investigated the risk of severe COVID-19 illness among children with underlying medical conditions and medical complexity. It found that children with type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity had a higher risk of severe COVID-19 illness, highlighting the importance of close observation and cautious clinical management for these children.

JAMA NETWORK OPEN (2021)

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Article Pediatrics

COVID 19 Vaccine for Adolescents. Concern about Myocarditis and Pericarditis

Giuseppe Calcaterra et al.

Summary: Health regulators in the US and Europe are investigating the potential link between COVID-19 mRNA vaccines and myocarditis in adolescent males. There is currently no evidence to suggest that these cases of heart inflammation are related to other diseases.

PEDIATRIC REPORTS (2021)

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Article Public, Environmental & Occupational Health