The imperfect science of neonatal sepsis

Review Pediatrics

Neonatal sepsis definitions from randomised clinical trials

Rian Hayes et al.

Summary: Neonatal sepsis, a leading cause of infant mortality, has diverse definitions based on microbiological culture, laboratory tests, and clinical signs. An international consensus-based definition could improve research comparability and clinical outcomes.

PEDIATRIC RESEARCH (2023)

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Article Critical Care Medicine

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021

Laura Evans et al.

CRITICAL CARE MEDICINE (2021)

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Article Medicine, General & Internal

Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection

Noa Fleiss et al.

Summary: Through a multicenter retrospective cohort study at 7 academic neonatal intensive care units, it was found that the nSOFA score was associated with late-onset infection mortality in preterm infants, suggesting it may serve as the foundation for a consensus definition of sepsis in this population.

JAMA NETWORK OPEN (2021)

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Article Pediatrics

Early-Onset Sepsis Among Very Preterm Infants

Dustin D. Flannery et al.

Summary: This study investigated the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants from 2018 to 2019. The findings revealed an incidence rate of 13.5 per 1000 very preterm births, with Escherichia coli and group B Streptococcus being the most common pathogens. Infected infants had longer hospital stays and lower survival rates, emphasizing the need for novel preventive strategies.

PEDIATRICS (2021)

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Article Medicine, General & Internal