4.5 Article

Improved Hematologic Outcomes in HIV1-Exposed Infants Receiving Nevirapine Compared With Zidovudine for Postnatal Prophylaxis in a High Resource Setting

期刊

PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 41, 期 5, 页码 420-423

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000003478

关键词

HIV1; perinatal transmission; anemia; nevirapine; zidovudine

资金

  1. National Agency for Research on HIV/AIDS and Hepatitis
  2. French National Agency for AIDS Research (ANRS)
  3. ViiV Healthcare
  4. Bristol-Myers Squibb
  5. Janssen Cilag
  6. Gilead Sciences
  7. MSD France

向作者/读者索取更多资源

In the ANRS French Perinatal Cohort, it was found that nevirapine (NVP) had a lower frequency of anemia grade >= 2 compared to zidovudine (AZT) in infants at low risk of HIV acquisition.
In the ANRS French Perinatal Cohort, we compared outcomes in 830 HIV1-exposed infants who received either nevirapine (NVP) or zidovudine postnatal prophylaxis. At 1 month, anemia grade >= 2 was less frequent on NVP than zidovudine (2.9% vs. 8.0%; P = 0.01), favoring the use of NVP as a first choice prophylaxis in infants at low risk of HIV acquisition.

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