期刊
PEDIATRIC CRITICAL CARE MEDICINE
卷 23, 期 2, 页码 E111-E119出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PCC.0000000000002814
关键词
cardiopulmonary bypass; cell-free plasma hemoglobin; hemolysis; hyperoxia; pediatrics
资金
- University of Pittsburgh Clinical and Translational Science Institute [UL1 TR000005]
- NIH [T32HD040686, K12HL109068, K23HD100553]
This study investigates potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and identifies younger age and higher mean Pao(2) x cardiopulmonary bypass duration as risk factors. Severe hemolysis is associated with longer hospital and ICU lengths of stay as well as acute kidney injury.
OBJECTIVES: To determine potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and examine whether supraphysiologic levels of oxygen and cardiopulmonary bypass duration are associated with hemolysis. DESIGN: Prospective observational study. SETTING: Cardiac ICU in a university-affiliated children's hospital. PATIENTS: Greater than 1 month to less than 18 years old patients undergoing cardiopulmonary bypass for cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Plasma samples from 100 patients to assess cell-free plasma hemoglobin levels were obtained at start cardiopulmonary bypass, at the end of cardiopulmonary bypass, and 2 and 24 hours after reperfusion. Arterial blood gas samples were obtained before and every 30 minutes during cardiopulmonary bypass. Patient demographics and laboratory data were collected from the electronic medical record. Plasma hemoglobin levels peaked at the end of cardiopulmonary bypass and haptoglobin levels continued to fall throughout all time points. There were 44 patients with severe hemolysis (change in cell-free plasma hemoglobin > 50 mg/dL). Younger age (odds ratio/sd 0.45 [95% CI, 0.25-0.81]) and higher mean Pao(2) x cardiopulmonary bypass duration (31.11 [1.46-664.64]) were identified as risk factors for severe hemolysis in multivariable analysis. Severe hemolysis was associated with longer hospital and ICU lengths of stay as well as acute kidney injury. CONCLUSIONS: We observed younger age and the exposure to both oxygen and duration of cardiopulmonary bypass as risk factors for hemolysis. Oxygen delivery through the cardiopulmonary bypass circuit is an easily modifiable risk factor. Its role in the production of reactive oxygen species that could alter the erythrocyte membrane deserves further examination in larger prospective studies.
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