Childhood multisystem inflammatory syndrome associated with COVID-19 (MIS-C): Distinct from Kawasaki disease or part of the same spectrum?

Review Immunology

SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Vanessa Sancho-Shimizu et al.

Summary: MIS-C, a newly emerging syndrome in children associated with COVID-19, shows heterogeneity resembling KD, possibly triggered by viruses and potentially linked to rare inborn errors of immunity altering the immune response. Discovery of monogenic IEIs underlying MIS-C may pave the way for a new genetic approach to classic KD.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Pediatrics

Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Marco Cattalini et al.

Summary: The study indicates that SARS-CoV-2 infection can lead to two distinct inflammatory diseases in children: Kawasaki Disease and PIMS-TS. Older age and clinical peculiarities like myocarditis characterize this multi-inflammatory syndrome, with patients showing optimal response to treatments, few complications, and no deaths.

PEDIATRIC RHEUMATOLOGY (2021)

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Article Pediatrics

Multisystem Inflammatory Syndrome in Children: Unique Disease or Part of the Kawasaki Disease Spectrum?

Caterina Matucci-Cerinic et al.

Summary: During the COVID-19 pandemic, MIS-C has emerged as a mysterious and intriguing phenomenon in children and adolescents, showing overlapping features with KD but also distinct clinical characteristics. Treatment involves IVIG, glucocorticoids, and anakinra, with ongoing debate over whether MIS-C and KD are separate illnesses or part of the same spectrum.

FRONTIERS IN PEDIATRICS (2021)

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Article Medicine, General & Internal