Role of air pollutants mediated oxidative stress in respiratory diseases

Airborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidative potential of PM2.5 can be evaluated with the dithiothreitol (DTT) dosage, which represents both ROS chemically produced and intracellular ROS of macrophages. This correlates with quality indicators of the internal environment and ventilation strategies such as dilution and removal of airborne contaminants.

Automated summary

Airborne particulate components from fossil fuel combustion can cause oxidative stress and airway inflammation, which can be indicated by fractionated exhaled nitric oxide. The oxidative potential of PM2.5 can be assessed using the dithiothreitol dosage, reflecting the quality indicators of the internal environment and ventilation strategies.