Contribution of circRNAs in gastric cancer

Gastric cancer (GC) is one of the most commonly diagnosed neoplasms in the world. A number of environmental and lifestyle factors, particularly chronic infection with Helicobacter pylori, have been found to partake in the pathogenesis of GC. The advent of high-throughput genome and transcriptome analysis has enhanced the knowledge about molecular mechanisms of the pathogenesis of GC. However, data regarding the expression of several circRNAs, such as circLMTK2, are not consistent. We explain the role of circRNAs in the development of GC. We searched databases for the newest publications using the terms gastric cancer and circRNA. Each circRNA alteration, downstream targets, its impacts on cancer cells, and the prognostic and diagnostic roles of these circRNAs have been discussed. Taken together, circRNAs can be putative biomarkers in GC and potential targets for the treatment of this cancer. Yet, this field is still in its infancy and needs further experiments for reaching the clinical application. As these transcripts are stable in circulation, they can be used in non-invasive methods of cancer detection and patients' follow-up.

Automated summary

Gastric cancer is closely related to environmental factors such as chronic infection with Helicobacter pylori, and high-throughput genome and transcriptome analysis has provided insights into its molecular mechanisms. However, data on circRNA expression in gastric cancer remains inconsistent, requiring further investigation. CircRNA could potentially serve as biomarkers and therapeutic targets for gastric cancer, yet more experiments are needed for clinical application.