4.5 Review

A review on the role of GAS6 and GAS6-AS1 in the carcinogenesis

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Article Pathology

Opposite trends of GAS6 and GAS6-AS expressions in breast cancer tissues

Ali Lavasani et al.

Summary: GAS6 and GAS6-AS1 play critical roles in the pathogenesis of breast cancer, with up-regulated expression of GAS6 in cancer tissues and down-regulated expression of GAS6-AS1 in tumor tissues.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2021)

Article Medicine, Research & Experimental

lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1

Jing Luo et al.

Summary: The study identified GAS6-AS1 as a novel tumor suppressor in LUAD by inhibiting glucose metabolism reprogramming through regulation of GLUT1, offering potential prognostic and therapeutic implications for patients.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Biochemistry & Molecular Biology

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway

Wenwen Du et al.

Summary: This study demonstrates for the first time that PD-L1 regulates NSCLC cell proliferation through the Gas6/MerTK signaling pathway, and reveals a molecular mechanism by which PD-L1 translocates into the nucleus to promote Gas6 synthesis and activate the MerTK signaling pathway. These findings provide potential implications for PD-L1 targeted immunotherapy in the clinic.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biotechnology & Applied Microbiology

Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling

Minhai Dong et al.

CANCER GENE THERAPY (2020)

Article Biotechnology & Applied Microbiology

Overexpression of GAS6 Promotes Cell Proliferation and Invasion in Bladder Cancer by Activation of the PI3K/AKT Pathway

Shiyu Mao et al.

ONCOTARGETS AND THERAPY (2020)

Review Medicine, Research & Experimental

Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants

Soudeh Ghaforui-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Stromal Gas6 promotes the progression of premalignant mammary cells

Angelica M. Gomes et al.

ONCOGENE (2019)

Review Biochemistry & Molecular Biology

The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers

Anton Scott Goustin et al.

NON-CODING RNA (2019)

Article Dentistry, Oral Surgery & Medicine

Gas6 protein induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma

Kelsey M. Hirschi et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2018)

Article Oncology

AXL-GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases

Xiaoliang Wu et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

S. Ammoun et al.

ONCOGENE (2014)

Article Multidisciplinary Sciences

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

Erinn B. Rankin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma. patients

Ju Han et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Oncology

Inhibitory role of Gas6 in intestinal tumorigenesis

Reiko Akitake-Kawano et al.

CARCINOGENESIS (2013)

Article Cell Biology

Biology of the TAM Receptors

Greg Lemke

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Meta-Analysis of Microarray Data Identifies GAS6 Expression as an Independent Predictor of Poor Survival in Ovarian Cancer

Michelle Buehler et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Oncology

Hypoxia Stabilizes GAS6/Axl Signaling in Metastatic Prostate Cancer

Anjali Mishra et al.

MOLECULAR CANCER RESEARCH (2012)

Article Oncology

Growth arrest-specific gene 6 expression in human breast cancer

O. Mc Cormack et al.

BRITISH JOURNAL OF CANCER (2008)

Article Biochemistry & Molecular Biology

Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway

Tateo Sawabu et al.

MOLECULAR CARCINOGENESIS (2007)

Article Biochemistry & Molecular Biology

Gas6 induces mesangial cell proliferation via latent transcription factor STAT3

M Yanagita et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)