4.2 Article

PCBP2 knockdown promotes ferroptosis in malignant mesothelioma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis

Zhen Cheng et al.

Summary: The study found that A/J strain mice have higher susceptibility to Fe-NTA-induced renal cell carcinoma due to differential expression of genes related to ferroptosis and iron metabolism. A/J mice maintained higher levels of glutathione peroxidase 4 and xCT (SLC7A11) expression after Fe-NTA treatment, leading to lower lipid peroxidation levels.

CANCER SCIENCE (2022)

Article Oncology

PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E

Xiaonan Wang et al.

Summary: The study found that there was a discrepancy between mRNA and protein levels of PCBP2 in breast cancer cells, and the expression of PCBP2 protein was significantly associated with disease progression and poor outcomes in patients. The research also highlighted that alternative splicing and polyadenylation of PCBP2 3'UTR play a role in regulating its expression levels, contributing to breast cancer progression.

MOLECULAR CANCER RESEARCH (2021)

Article Respiratory System

Update on biology and management of mesothelioma

Rachelle Asciak et al.

Summary: Malignant pleural mesothelioma is an aggressive and incurable cancer usually linked to asbestos exposure. The disease is heterogeneous in presentation and behavior, making diagnosis difficult. Current treatment options are largely ineffective, but there have been significant advances in understanding the biology and pathogenesis of the disease.

EUROPEAN RESPIRATORY REVIEW (2021)

Article Multidisciplinary Sciences

Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine

Sean F. Jordan et al.

Summary: Iron-sulfur (FeS) proteins are ancient and fundamental to life, being involved in electron transfer and CO2 fixation. The study demonstrates that FeS clusters can spontaneously form in the presence of the amino acid cysteine under conditions similar to Hadean alkaline hydrothermal vents, suggesting a plausible mechanism for their emergence at the origin of life.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin

Fumiya Ito et al.

Summary: The study proposed a novel mechanism in which extracellular vesicles mediate the transfer of mutagenic factors associated with asbestos to mesothelial cells. It was found that FedEVs transport iron from ferroptotic macrophages to mesothelial cells, contributing to asbestos-induced mesothelioma. Mesothelial cells receiving higher amounts of FedEVs were found to be in mitotic phases, particularly in S and G2/M phases.

REDOX BIOLOGY (2021)

Review Medicine, Research & Experimental

Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer

Chendong Yuan et al.

Summary: PCBP2 is an RNA-binding protein that is considered as an oncogene in cancer development, promoting tumor growth and metastasis. Research on PCBP2 may provide novel biomarkers for cancer prognosis and therapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Hematology

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles

Izumi Yanatori et al.

Summary: Extracellular vesicles (EVs) transfer functional molecules between cells, with CD63 expression regulated by the IRE-IRP system in response to iron levels. Under iron loading, cellular ferritin is transferred via NCOA4 to CD63(+) EVs for secretion, providing insight into the local exchange of ferritin and iron between cells.
Review Oncology

Ferroptosis at the crossroads of infection, aging and cancer

Shinya Toyokuni et al.

CANCER SCIENCE (2020)

Review Biochemistry & Molecular Biology

Iron and redox cycling. Do's and don'ts

W. H. Koppenol et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Biochemistry & Molecular Biology

DMT1 and iron transport

Izumi Yanatori et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Cell Biology

Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor

Jihua Guo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

The ins and outs of iron: Escorting iron through the mammalian cytosol

Caroline C. Philpott et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Multidisciplinary Sciences

Specific binding of PCBP1 to heavily oxidized RNA to induce cell death

Takashi Ishii et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Environmental Sciences

Global Asbestos Disaster

Sugio Furuya et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Biochemistry & Molecular Biology

Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2

Izumi Yanatori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Cell Biology

Ironing out Ferroportin

Hal Drakesmith et al.

CELL METABOLISM (2015)

Article Biochemistry & Molecular Biology

Chaperone protein involved in transmembrane transport of iron

Izumi Yanatori et al.

BIOCHEMICAL JOURNAL (2014)

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Review Pharmacology & Pharmacy

Genotoxicity and carcinogenicity risk of carbon nanotubes

Shinya Toyokuni

ADVANCED DRUG DELIVERY REVIEWS (2013)

Review Biochemistry & Molecular Biology

Hepcidin and iron homeostasis

Tomas Ganz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Oncology

Iron overload signature in chrysotile-induced malignant mesothelioma

Li Jiang et al.

JOURNAL OF PATHOLOGY (2012)

Article Oncology

Asbestos surface provides a niche for oxidative modification

Hirotaka Nagai et al.

CANCER SCIENCE (2011)

Article Cell Biology

The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo

Toshiro Moroishi et al.

CELL METABOLISM (2011)

Article Multidisciplinary Sciences

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

Hirotaka Nagai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Biopersistent fiber-induced inflammation and carcinogenesis: Lessons learned from asbestos toward safety of fibrous nanomaterials

Hirotaka Nagai et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Article Medicine, Research & Experimental

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma

Qian Hu et al.

LABORATORY INVESTIGATION (2010)

Article Multidisciplinary Sciences

A cytosolic iron chaperone that delivers iron to ferritin

Haifeng Shi et al.

SCIENCE (2008)

Review Biochemistry & Molecular Biology

Novel aspects of oxidative stress-associated carcinogenesis

Shinya Toyokuni

ANTIOXIDANTS & REDOX SIGNALING (2006)

Article Medicine, Research & Experimental

Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis

KK Dutta et al.

LABORATORY INVESTIGATION (2005)

Review Biochemistry & Molecular Biology

The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms

AV Makeyev et al.