4.2 Article

PSOP1, putative secreted ookinete protein 1, is localized to the micronemes of Plasmodium yoelii and P. berghei ookinetes

期刊

PARASITOLOGY INTERNATIONAL
卷 84, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2021.102407

关键词

Plasmodium; Ookinete; Microneme; PSOP1; Malaria

资金

  1. JSPS KAKENHI [JP20H03480]

向作者/读者索取更多资源

The development and traversal of Plasmodium parasites in the mosquito midgut is a major bottleneck in the parasite's life cycle. PSOP1 protein is predicted to be involved in migration across the midgut wall, and its localization in micronemes suggests a role in parasite-host interactions during ookinete penetration.
Plasmodium parasites cause malaria in mammalian hosts and are transmitted by Anopheles mosquitoes. Activated gametocytes in the mosquito midgut egress from erythrocytes followed by fertilization and zygote formation. Zygotes differentiate into motile invasive ookinetes, which penetrate the midgut epithelium before forming oocysts beneath the basal lamina. Ookinete development and traversal across the mosquito midgut wall are major bottlenecks in the parasite life cycle. In ookinetes, surface proteins and proteins stored in apical organelles have been shown to be involved in parasite-host interactions. A group of ookinete proteins that are predicted to have such functions are named PSOPs (putative secreted ookinete protein). PSOP1 is possibly involved in migration through the midgut wall, and here its subcellular localization was examined in ookinetes by immunoelectron microscopy. PSOP1 localizes to the micronemes of Plasmodium yoelii and Plasmodium berghei ookinetes, indicating that it is stored and possibly apically secreted during ookinete penetration through the mosquito midgut wall.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据