期刊
PAIN
卷 163, 期 10, 页码 2014-2020出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/j.pain.0000000000002597
关键词
Spinal cord; Lamina X; Primary afferents; Nociception; Segmental control; Descending regulation; Presynaptic inhibition; Dorsolateral funiculus; Anterior funiculus; Corticospinal tract
资金
- NASU [0120U00, 0118U007345]
- H2020 grants [857562 NEUROTWIN]
- [PTDC/NEU-NMC/1259/2014 POCI-01-0145-FEDER-016588]
- [POCI-01-0145-FEDER-016385]
This study reveals the input sources and regulation mechanisms of spinal lamina X neurons, demonstrating that primary afferent fibers are regulated by both spinal and supraspinal control through at least 5 distinct pathways.
Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X remains one of the least studied central nervous system regions. Here, we show that A delta- and C-afferent inputs to lamina X neurons are presynaptically inhibited by homo- and heterosegmental afferents as well as by descending fibers from the corticospinal tract, dorsolateral funiculus, and anterior funiculus. Activation of descending tracts suppresses primary afferent-evoked action potentials and also elicits excitatory (mono- and polysynaptic) and inhibitory postsynaptic responses in lamina X neurons. Thus, primary afferent input to lamina X is subject to both spinal and supraspinal control being regulated by at least 5 distinct pathways.
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