G-Protein Coupled Receptor 35 Induces Intervertebral Disc Degeneration by Mediating the Influx of Calcium Ions and Upregulating Reactive Oxygen Species

Article Cell Biology

Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration

Jiancheng Zheng et al.

Summary: The study identified ROS as the primary inducer of LBP, involving ROS stimulation of NPCs to secrete SP, promoting LBP in IVDs. Therefore, reducing ROS levels and inhibiting SP could be alternative methods for treating LBP.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biochemistry & Molecular Biology

GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway

Yao Zhang et al.

Summary: The expression of GPR35 in bone marrow mesenchymal stem cells is suppressed in osteoporosis patients and mice, affecting osteogenic differentiation. GPR35 deficiency impairs the function of BMSCs, while overexpression contributes to osteogenesis. The synthetic GPR35 agonist zaprinast can reduce bone loss and promote bone generation, suggesting a potential novel treatment for osteoporosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cell Biology

Mechanical and chemical activation of GPR68 probed with a genetically encoded fluorescent reporter

Alper D. Ozkan et al.

Summary: The study developed a genetically encoded fluorescent reporter, iGlow, by inserting a fluorescent protein into the third intracellular loop of GPR68, which responds to physiological GPR68 activators and synthetic agonists with specificity. iGlow activation is unaffected by pharmacological modulation of downstream G-protein signaling or disruption of actin filaments, providing a new tool for investigating GPR68-dependent signaling in health and disease.

JOURNAL OF CELL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

Yi Sun et al.

Summary: G protein coupled estrogen receptor (GPER) plays a critical role in regulating mechanical stress-mediated signal transduction and chondrocyte apoptosis. The potential application of GPER as a therapy target for osteoarthritis (OA) has been elucidated.

MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases

Yan Zhou et al.

Summary: ER stress is closely associated with the pathogenesis of diabetes and obesity, with excess nutrients and inflammatory cytokines as triggers. It not only induces endothelial dysfunction and atherosclerosis, but also contributes to oxidative stress.

ANTIOXIDANTS (2021)

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Article Multidisciplinary Sciences