期刊
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/1458143
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类别
资金
- Science and Technology Strategic Cooperation Project of the Luzhou People's Government and Southwest Medical University [2019LZXNYDJ34]
- Undergraduate Innovation and Entrepreneurship Training Program [S202010632282]
Artemisinin and its derivatives have shown antitumor effects in addition to their antimalarial properties. The mechanisms of antitumor activity involve cell cycle regulation, inhibition of tumor angiogenesis, DNA damage, and induction of ferroptosis. This review focuses on the potential of artemisinin derivatives in regulating ferroptosis and provides a basis for their use as anticancer drugs in clinical practice.
Artemisinin (ART) is a bioactive molecule derived from the Chinese medicinal plant Artemisia annua (Asteraceae). ART and artemisinin derivatives (ARTs) have been effectively used for antimalaria treatment. The structure of ART is composed of a sesquiterpene lactone, including a peroxide internal bridge that is essential for its activity. In addition to their well-known antimalarial effects, ARTs have been shown recently to resist a wide range of tumors. The antineoplastic mechanisms of ART mainly include cell cycle inhibition, inhibition of tumor angiogenesis, DNA damage, and ferroptosis. In particular, ferroptosis is a novel nonapoptotic type of programmed cell death. However, the antitumor mechanisms of ARTs by regulating ferroptosis remain unclear. Through this review, we focus on the potential antitumor function of ARTs by acting on ferroptosis, including the regulation of iron metabolism, generation of reactive oxygen species (ROS), and activation of endoplasmic reticulum stress (ERS). This article systematically reviews the recent progress in ferroptosis research and provides a basis for ARTs as an anticancer drug in clinical practice.
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