4.5 Article

Time dependency in early major osteoporotic and hip re-fractures in women and men aged 50 years and older: a population-based observational study

期刊

OSTEOPOROSIS INTERNATIONAL
卷 33, 期 1, 页码 39-46

出版社

SPRINGER LONDON LTD
DOI: 10.1007/s00198-021-06166-0

关键词

Fracture; FRAX; Imminent fracture; Major osteoporotic fracture; Osteoporosis; Population-based cohort study

资金

  1. Tier 1 Canada Research Chair

向作者/读者索取更多资源

The study found that the risk of recurrent fracture following a first major osteoporotic fracture remains elevated over 10 years, with modest and inconsistent attenuation in risk over time. Time dependency in early fracture risk was observed to be inconsistent, especially in women over the age of 65.
We analyzed patterns in recurrent major osteoporotic fracture (MOF) following a first major osteoporotic fracture in a large population-based cohort. Re-fracture risk remained elevated over 10 years, with only modest and inconsistent attenuation in risk over time. Introduction Recurrent fracture risk remains elevated for up to 25 years, and is reportedly highest in the initial 2 years (imminent risk). Our aim was to characterize early time dependency in re-fracture rates up to 10 years after a first fracture in a population-based cohort. Methods Using Province of Manitoba (Canada) healthcare databases, we performed a matched cohort study in 22,105 women (mean age 74.1 +/- 10.6 years) and 7589 men (mean age 71.8 +/- 11.2 years) after a first MOF (age >= 50 years) during 1989-2006 and matched fracture-free controls (3 for each case). Incident fractures were ascertained over the next 10 years. Fracture rate ratios (RRs, cases versus controls) stratified by sex and age were computed, and tested for linear trend using linear regression. Joinpoint regression was performed to determine non-linear change in fracture rates over time, with particular attention to the first 2-year post-fracture. Results RRs for incident MOF and hip fracture exceeded unity for the primary analyses in all subgroups and follow-up intervals. There was a tendency of RRs to decline over time, but this was inconsistent. Absolute rates per 100,000 person-years for fracture cases were consistently greater than for controls in all subgroups and observation times. Among fracture cases, there was a tendency for rates to decline gradually in all subgroups except younger women, but these temporal trends appeared monotonic without an inflection at 2 years. Joinpoint regression analyses did not detect an inflection in risk between the first 2 years and subsequent years. No significant time dependency was seen for incident hip fracture. Conclusions MOF and hip re-fracture risk was elevated in all age and sex subgroups over 10 years. There was inconsistent and only modest time dependency in early MOF risk, most evident in women after age 65 years. No strong transition in risk was seen between the first 2-year post-fracture and subsequent years.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据