期刊
OSTEOARTHRITIS AND CARTILAGE
卷 30, 期 2, 页码 237-248出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2021.11.001
关键词
Biomarkers; Protein; Diagnosis; Osteoarthritis; Prognosis; Review
Recent studies have focused on the application of protein-derived soluble biomarkers in osteoarthritis, with research areas including disease burden, investigative biomarkers, prognosis, treatment efficacy, and the diagnostic and phenotyping value of these biomarkers. These studies contribute to a more targeted management of patients suffering from osteoarthritis.
Objective: To summarize recent scientific advances in protein-derived soluble biomarkers of osteoarthritis. Design: A systematic search on the PubMed electronic database of clinical studies on protein-derived soluble biochemical markers of osteoarthritis in humans that were published between January 1st 2020 and March 31th 2021. The studies were selected on the basis of objective criteria and summarized in a table. Then they were described in a narrative review. Results: Out of 1971 publications, 48 fulfilled all selection criteria and 16 were selected by the author for the narrative review. The papers were classified according their clinical significance as defined in the BIPEDS classification. Two papers investigated the burden of disease, two were dedicated to investigative biomarkers, four papers question the prognosis, three the efficacy of treatment and five the diagnosis and phenotyping value of protein-derived biomarkers. Conclusions: Currently, biomarkers research is focused on their use as tools to identify molecular endotypes and clinical phenotypes and to facilitate patient screening and monitoring in clinical trials. This approach should allow a more targeted management of patients suffering from osteoarthritis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据