4.6 Article

ERK1/2-mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Orthopedics

Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c

M. Y. Ansari et al.

Summary: Lysosomal dysfunction in aged and OA cartilage leads to chondrocyte apoptosis, increased oxidative stress, and accumulation of dysfunctional mitochondria. Inhibiting lysosomal function results in BAX-mediated mitochondrial damage and release of Cytochrome c, inducing apoptosis in chondrocytes. Restoring lysosomal function and inhibiting BAX may be a potential therapeutic approach for OA.

OSTEOARTHRITIS AND CARTILAGE (2021)

Review Medicine, Research & Experimental

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

Mohammad Yunus Ansari et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease

Anne Jessica Roe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Cardiac & Cardiovascular Systems

Inhibition of ERK-Drpl signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure

Chih-Yang Huang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Review Multidisciplinary Sciences

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

Andrey S. Marchev et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Article Multidisciplinary Sciences

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

Javier Prieto et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis

Edith Charlier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

Jennifer A. Kashatus et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

Aswin Pyakurel et al.

MOLECULAR CELL (2015)

Review Clinical Neurology

Disturbed mitochondrial dynamics and neurodegenerative disorders

Florence Burte et al.

NATURE REVIEWS NEUROLOGY (2015)

Article Biochemistry & Molecular Biology

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

Xueqi Gan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

Michael H. Yan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Cell Biology

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

Oliver C. Loson et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Review Multidisciplinary Sciences

Mitochondrial Fission, Fusion, and Stress

Richard J. Youle et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress

X. Liu et al.

CELL DEATH AND DIFFERENTIATION (2011)

Review Rheumatology

The role of mitochondria in osteoarthritis

Francisco J. Blanco et al.

NATURE REVIEWS RHEUMATOLOGY (2011)

Article Ophthalmology

A Selective Inhibitor of Drp1, Mdivi-1, Increases Retinal Ganglion Cell Survival in Acute Ischemic Mouse Retina

Sang Woo Park et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Cell Biology

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

Chuang-Rung Chang et al.

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

Sylvie Montessuit et al.

Review Genetics & Heredity

The Role of Mitochondria in Apoptosis

Chunxin Wang et al.

ANNUAL REVIEW OF GENETICS (2009)

Article Cardiac & Cardiovascular Systems

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

Tianzheng Yu et al.

CARDIOVASCULAR RESEARCH (2008)

Review Rheumatology

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis

Richard F. Loeser et al.

CURRENT OPINION IN RHEUMATOLOGY (2008)

Article Multidisciplinary Sciences

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

TZ Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cell Biology

Mitochondrial dysfunction in osteoarthritis

FJ Blanco et al.

MITOCHONDRION (2004)

Article Cell Biology

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

E Smirnova et al.

MOLECULAR BIOLOGY OF THE CELL (2001)