Radical Alkene-Trifluoromethylation-Triggered Nitrile Insertion/Remote Functionalization Relay Processes: Diverse Synthesis of Trifluoromethylated Azaheterocycles Enabled by Copper Catalysis

A copper-catalyzed alkene-trifluoromethylation-triggered nitrile insertion/remote functionalization relay process has been achieved, in which interrupted remote 1,n-difunctionalizations of alkenes with nitrite insertion can deliver iminyl radical intermediates instead of C-based radicals, followed by subsequent 1,n-HAT to furnish corresponding remote functionalization. This relay protocol enables a straightforward approach to streamline the assembly of structurally diverse trifluoromethylated azaheterocycles.

Automated summary

A copper-catalyzed alkene-trifluoromethylation-triggered nitrile insertion/remote functionalization relay process has been developed, which involves the generation of iminyl radical intermediates through interrupted remote 1,n-difunctionalizations of alkenes with nitrite insertion, followed by subsequent 1,n-HAT to achieve remote functionalization. This relay protocol provides a straightforward approach for the assembly of structurally diverse trifluoromethylated azaheterocycles.