期刊
ORGANIC LETTERS
卷 23, 期 22, 页码 8683-8687出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02986
关键词
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资金
- National Key R&D Program of China [2018YFA0702001]
- NSFC [21901235, 22071224]
- USTC [KY2060000121, WK2060190095, KY2060000143]
- USTC Research Funds of the Double First-Class Initiative [YD2060002010]
- Anhui Provincial Natural Science Foundation [1908085MB34]
The asymmetric synthesis of allylic P-stereogenic phosphinates from H-phosphinates has been successfully developed, achieving high enantioselectivities of up to 92% ee and generally high yields. Furthermore, this method is applicable for scale-up synthesis and facile transformation of chiral products from phosphinates to phosphine oxides under mild reaction conditions, demonstrating its versatility and practicality.
The asymmetric synthesis of P-stereogenic phosphinates through allylic alkylation of H-phosphinates has been developed. With Hphosphinates and allylic acetates as the starting materials, a variety of allylic P-chiral phosphinates were accessed in high enantioselectivities of up to 92% ee and generally high yields. In addition, a further study demonstrated the applicability of this protocol, including the scale-up synthesis and facile transformation of chiral products from phosphinates to phosphine oxides with organolithium reagents under mild reaction conditions.
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