期刊
ORGANIC LETTERS
卷 24, 期 3, 页码 916-920出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c04267
关键词
-
资金
- National Institute of Dental and Craniofacial Research Grant [R21DE029156]
Here, we report the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method shows good yields in converting primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds, including derivatives of complex bioactive molecules.
Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据