Enantioselective Rhodium-Catalyzed Hydrogenation of (Z)-N-Sulfonyl-α-dehydroamido Boronic Esters

Highly enantioselective rhodium-catalyzed hydrogenation of (Z)-N-sulfonyl-alpha-dehydroamido boronic esters is realized for the first time using a JosiPhos-type ligand. This method has enabled convenient synthesis of a series of enantio-enriched N-sulfonyl-alpha-amido boronic esters in good yields and excellent enantioselectivities (up to 99% ee).

Automated summary

Highly enantioselective hydrogenation of (Z)-N-sulfonyl-α-dehydroamido boronic esters using a JosiPhos-type ligand is realized for the first time. This method enables the convenient synthesis of a series of enantio-enriched N-sulfonyl-α-amido boronic esters with good yields and excellent enantioselectivities (up to 99% ee).