4.8 Article

Construction of the Tetracyclic Core Structure of Dysiherbols A-C

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ORGANIC LETTERS
卷 24, 期 8, 页码 1642-1646

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00159

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  1. NSFC [21901170, 21921002, U19A2014]
  2. Sichuan University [2020SCUNL204]

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This study presents a synthetic approach to the tetracyclic core structure of Dysiherbols A-C. The synthesis involves the intramolecular [2 + 2] cycloaddition to introduce a fused 6/4 ring system, followed by a Pd-catalyzed semipinacol rearrangement/C-sp2-H arylation cascade to construct ring C, and a visible-light-mediated ring-opening of cyclopropyl silyl ether to install the tetracyclic core of Dysiherbols.
A synthetic study on the construction of the tetracyclic core structure of dysiherbols A-C is presented herein. In this synthesis, intramolecular [2 + 2] cycloaddition introduces a fused 6/4 ring system, followed by a Pd-catalyzed semipinacol rearrangement/C-sp2-H arylation cascade to construct the ring C, and visible-light-mediated ring-opening of cyclopropyl silyl ether installs the tetracyclic core of dysiherbols.

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