Construction of the Tetracyclic Core Structure of Dysiherbols A-C

A synthetic study on the construction of the tetracyclic core structure of dysiherbols A-C is presented herein. In this synthesis, intramolecular [2 + 2] cycloaddition introduces a fused 6/4 ring system, followed by a Pd-catalyzed semipinacol rearrangement/C-sp2-H arylation cascade to construct the ring C, and visible-light-mediated ring-opening of cyclopropyl silyl ether installs the tetracyclic core of dysiherbols.

Automated summary

This study presents a synthetic approach to the tetracyclic core structure of Dysiherbols A-C. The synthesis involves the intramolecular [2 + 2] cycloaddition to introduce a fused 6/4 ring system, followed by a Pd-catalyzed semipinacol rearrangement/C-sp2-H arylation cascade to construct ring C, and a visible-light-mediated ring-opening of cyclopropyl silyl ether to install the tetracyclic core of Dysiherbols.