期刊
ORGANIC LETTERS
卷 24, 期 1, 页码 304-308出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03967
关键词
-
资金
- NSFC [21925109, 21772170]
- Open Research Fund of School Chemistry and Chemical Engineering, Henan Normal University
- Center of Chemistry for Frontier Technologies of Zhejiang University
A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was carried out using the chiral ligand L-pGlu-OH, resulting in the synthesis of enantioenriched N-aryl peptoid atropisomers. High yields and excellent enantioselectivities were achieved, with up to 90% yield and 97% ee.
A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was developed for the synthesis of enantioenriched N-aryl peptoid atropisomers via beta-H elimination using commercially available and inexpensive L-pGlu-OH as a chiral ligand. Exclusive allylic selectivity was achieved. Additionally, a series of enantioenriched N-aryl peptoid atropisomers were obtained in synthetically useful yields with excellent enantioselectivities (up to 90% yield and 97% ee).
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