Carbon-Sulfur Bond Formation: Tandem Process for the Synthesis of Functionalized Isothiazoles

In this paper, we report a new process for the construction of 3,4,5-substituted isothiazoles via reaction cascades including Pummerer-like rearrangement, nucleophilic condensation, and sulfenamide cyclization followed by concomitant elimination and dehydration under mild reaction conditions. This process provides isothiazoles bearing fluorine and other functional groups in good to excellent yields from readily available starting materials.

Automated summary

A new process for the construction of 3,4,5-substituted isothiazoles is reported in this paper, utilizing reaction cascades including Pummerer-like rearrangement, nucleophilic condensation, and sulfenamide cyclization under mild conditions. This process provides good to excellent yields of isothiazoles bearing fluorine and other functional groups from readily available starting materials.