期刊
ORGANIC LETTERS
卷 23, 期 23, 页码 9163-9167出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03473
关键词
-
资金
- National Research Foundation of Korea (NRF) [NRF-2020R1F1A1048296, NRF-2 0 2 0 R 1 A 6 A 3 A 1 3 0 7 1 7 7 6, NRF-2021R1A2C2004476]
A novel guanidine C-N bond substitution strategy involving the formation of guanidine cyclic diimide (GCDI) structures is proposed to destabilize the resonance structure of the guanidine group. In the presence of acid additives, the guanidine carbon center of GCDIs undergoes nucleophilic substitution reactions with various amines and alcohols.
Despite the electron-deficient nature of the guanidine carbon centers, nucleophilic reactions at these sites have been underdeveloped because of the resonance stabilization of the guanidine group. We propose a guanidine C-N bond substitution strategy entailing the formation of guanidine cyclic diimide (GCDI) structures, which effectively destabilize the resonance structure of the guanidine group. In the presence of acid additives, the guanidine carbon center of GCDIs undergoes nucleophilic substitution reactions with various amines and alcohols.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据