Visible-Light-Promoted Aerobic Oxyphosphorylation of α-Diazoesters with H-Phosphine Oxides

A visible-light-promoted aerobic oxyphosphorylation of alpha-diazoesters and H-phosphine oxides has been developed. Using air as the oxygen source, the reaction proceeded smoothly at room temperature under blue-light irradiation. The alpha-diazoesters, molecular oxygen, and H-phosphine oxides are conveniently incorporated into a C-O-P(O) unit in one step. The preliminary mechanistic studies indicated that a light-triggered radical process is involved. The developed strategy shows the unrevealed reactivity of diazo compounds with H-phosphine oxides and has potential value in synthetic applications.

Automated summary

In this study, a visible-light-promoted aerobic oxyphosphorylation of alpha-diazoesters and H-phosphine oxides has been developed. The reaction proceeds smoothly at room temperature using air as the oxygen source and blue-light irradiation. Preliminary mechanistic studies indicate the involvement of a light-triggered radical process. This strategy reveals the previously unknown reactivity of diazo compounds with H-phosphine oxides and has potential value in synthetic applications.