Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds

A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described. Significantly, methanocycloocta[b]indoles were also obtained by sequential intramolecular dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations, and good yields. Moreover, the products exhibited potent antiproliferative activity against the human cancer cell lines by a MTT assay.

Automated summary

A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described, leading to the formation of methanocycloocta[b]indoles in some cases through sequential intramolecular dehydrocyclization process. The protocol offers a broad substrate scope, easy operation, and good yields, with the resulting products showing potent antiproliferative activity against human cancer cell lines in MTT assay.