期刊
ORGANIC LETTERS
卷 23, 期 23, 页码 9063-9067出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03314
关键词
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资金
- National Natural Science Foundation of China [22171168, 22001151]
- TaishanScholar Program of Shandong Province
- Shandong Provincial Natural Science Foundation [ZR2019QB004]
A base-catalyzed double annulation methodology has been developed for the efficient synthesis of 4-azafluorene and 4-azafluorenone derivatives. In contrast to traditional 1,3-dipolar reactions, the active methylene and isocyano groups of isocyanoacetate function as nucleophiles in this domino transformation.
A base-catalyzed double annulation of isocyanoacetates with various enynones has been developed for the expeditious synthesis of 4-azafluorene and 4-azafluorenone derivatives. Against the well-known 1,3-dipolar reactivities, the active methylene and isocyano groups of isocyanoacetate serve as nucleophiles in this domino transformation.
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