Synthesis of N-Fused Triazole-Piperazine-Quinazolinones via One-Pot Tandem Click Reaction and Cross-Dehydrogenative Coupling

Herein, a one-pot protocol to synthesize tetracyclic triazole-piperazine-quinazolinone-fused N-heterocyclic scaffolds is reported. In this strategy, a tandem approach of two highly efficient synthetic reactions, click and cross-dehydrogentive coupling reactions, with high atom economy were employed to obtain the target N-fused scaffolds. Being highly functional group tolerable, this method has broad substrate scope. Interestingly, some of these derivatives showed strong white solid-state fluorescence.

Automated summary

A one-pot protocol for synthesizing tetracyclic triazole-piperazine-quinazolinone-fused N-heterocyclic scaffolds is reported, utilizing tandem click and cross-dehydrogentive coupling reactions with high atom economy. The method is highly functional group tolerable and has a broad substrate scope, with some derivatives showing strong white solid-state fluorescence.