期刊
ORGANIC LETTERS
卷 23, 期 22, 页码 8783-8788出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03280
关键词
-
资金
- National Natural Science Foundation of China [21772109, 21971140]
- Beijing Natural Science Foundation [M21011]
This study successfully achieved the formal biomimetic synthesis of (+)-hippolachnin A guided by its plausible biosynthetic pathway. Key transformations include an intriguing [4 + 2] cycloaddition and a tandem rearrangement/dehydration reaction. The work not only provides a unified approach to access diverse plakortin-type polyketides but also offers convincing evidence to elucidate their underlying biosynthetic network.
A formal biomimetic synthesis of (+)-hippolachnin A has been achieved under the guidance of its plausible biosynthetic pathway. Pivotal transformations include an intriguing O-1(2)-mediated [4 + 2] cycloaddition and a tandem Kornblum-DeLaMare rearrangement/hemiketalization/dehydration reaction. The current work not only offers a unified approach to access skeletally diverse plakortin-type polyketides but also provides convincing evidence to elucidate their underlying biosynthetic network.
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