期刊
ORGANIC LETTERS
卷 23, 期 20, 页码 7751-7754出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02730
关键词
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资金
- National Key R&D Program of China [2019YFA0905700]
- National Natural Science Foundation of China [81874293, 81630093]
Two pairs of diastereoisomeric isoindoline alkaloids, xylarins A-D, were isolated from the endolichenic fungus Xylaria sp. Their structures and biological activities were determined, with compound 1 showing significant anti-thrombotic activity.
Two pairs of diastereoisomeric isoindoline alkaloids, xylarins A-D (1-4), were isolated from the endolichenic fungus Xylaria sp. Xylarins A and B (1 and 2) possess a previously undescribed 5/6/5-5/6 polycyclic scaffold, featuring a combination of a novel dihydrobenzofurone unit and an isoindoline unit, while xylarins C and D (3 and 4) contain an additional N,N-dimethylaniline at the C-3' position. Their structures were elucidated by comprehensive spectroscopic analyses combined with single-crystal X-ray diffraction and electronic circular dichroism calculations. The plausible biosynthetic pathways and gene clusters for 1-4 were proposed. Compound 1 exhibited significant antithrombotic activity.
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