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Bodipy-carbohydrate systems: synthesis and bio-applications

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 14, 页码 2742-2763

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob02459k

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Luminescent BODIPY-sugar probes have potential applications in bio-imaging, with unique structural and biological features conferred by carbohydrate units and outstanding photophysical properties of BODIPY derivatives. This article reviews the synthesis and applications of BODIPY-linked glycosyl probes, as well as the construction of multiBODIPY molecular systems and their functions.
Luminescent BODIPY-sugar probes have stimulated the attention of researchers for the potential applications of such molecular systems in bio-imaging. The presence of carbohydrate units confers unique structural and biological features, beside enhancement of water solubility and polarity. On the other hand, BODIPY (BOronDiPYrromethene) derivatives represent eclectic and functional luminescent molecules because of their outstanding photophysical properties. This article provides a review on the synthesis and applications of BODIPY-linked glycosyl probes in which the labelling of complex carbohydrates with BODIPY allowed the disclosing of their in vivo behaviour or where the sugar constitutes a recognition element for specific targeting probes, or, finally, in which the stereochemical characteristics of the carbohydrate hydroxyl groups play as structural elements for assembling more than one photoactive subunit, resulting in functional supramolecular molecules with modulable properties. We describe the methods we have used to construct various multiBODIPY molecular systems capable of functioning as artificial antennas exhibiting extremely efficient and fast photo-induced energy transfer. Some of these systems have been designed to allow the modulation of energy transfer efficiency and emission color, and intensity dependent on their position within a biological matrix. Finally, future perspectives for such BODIPY-based functional supramolecular sugar systems are also highlighted.

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