期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 2, 页码 352-357出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob02095a
关键词
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资金
- SERB-DST, the Govt. of India [CRG/2018/001111]
- DST-FIST
- UGC
- CSIR
A novel synthetic method for the preparation of highly substituted biologically relevant 2-aminonicotinonitriles with satisfactory yields is reported. This method involves creating two new C-N bonds under mild conditions and is applicable to gram-scale syntheses with excellent functional group tolerance.
A novel Cu(ii)-salt/DABCO-mediated one-pot access to a myriad of highly substituted biologically relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety with satisfactory yields is reported. This method involves cyclic sulfamidate imines as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C-N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method's practicability and allowing for a wide range of substrates with excellent functional group tolerance.
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